How to write a systematic literature review protocol

The Journal of clinical investigation. Furthermore, when myocardial infarction was induced in rats maintained on an alternate-day fasting diet, reduced infarction size, improved cardiac function, and increased survival was observed, compared to rats fed ad libitum 24,33, IGF, Insulin, and Cancer.

Referees are asked to assess the scientific validity of the article, rather than the novelty or interest levels. If any results are presented, are all the source data underlying the results available to ensure full reproducibility? For original research, this means that the experimental design, including controls and methods, is adequate; results are presented accurately and the conclusions are justified and supported by the data.

They should not be preliminary observations that need a later paper for validation. Calorie restriction in biosphere 2: Analgesia, which may be attributed to negative modulation of synaptic transmission in nociceptive neurons in the dorsal horn of the spinal cord, has also been reported in rats maintained on an alternate-day fasting diet Even well-designed randomized experiments will occasionally with low probability produce spurious results.

Authors usually start with a large number of identified records from their search and sequentially exclude records according to eligibility criteria.

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Are sufficient details of the code, methods and analysis if applicable provided to allow replication of the software development and its use by others?

Pearls and Pitfalls of Meta-analyses and Systematic Reviews. International Journal of Sports Medicine. The subjects were fasted on alternate days and reported an increased feeling of hunger from 37 to 56 mm and decrease in feeling of fullness from 43 to 23 mm when the dietary intervention was initiated.

Continuous passive motion following cartilage surgery: How than can we know what Really improved their life? When mice with progressive demyelinating disorders of the peripheral nervous system were put on an alternate-day fasting diet regime, hampered disease progression was observed as indicated by improved nerve morphology and performance compared to mice fed ad libitum Modified alternate-day fasting and loss of lean body mass was investigated in only one study in the systematic search.

All terms used are listed in Table 1. The results might — in some cases — be appropriate for inclusion in an article specifically dedicated to the treatment in question or to the researchers or businesses involved in it. Conversely, an older primary source that is seminal, replicated, and often-cited may be mentioned in the main text in a context established by reviews.

Loss of muscle mass One potential serious side effect of intermittent fasting would be loss of muscle mass. Regardless of the decision to combine individual study results, authors should report how they planned to evaluate between-study variability heterogeneity or inconsistency box 6.

Editors should not perform detailed academic peer review. Complications in Hip Arthroscopy: Journal of Orthopaedic Research.

Plagiarism — articles are checked for plagiarism before publication. Modified alternate-day fasting regimens reduce cell proliferation rates to a similar extent as daily calorie restriction in mice.

Such information, particularly when citing secondary sources, may be appropriate in research sections of disease articles. Additionally, the views of tiny minorities need not be reported. Standard deviations may have to be reconstructed from other statistics such as P values and t statistics, or occasionally they may be imputed from the standard deviations observed in other studies.

The data obtained to date suggest that calorie restriction slows aging in primates and improves health. Arthroscopy ; E-published March 23, For time-to-event outcomes, the hazard ratio is the most common summary measure.

Rats maintained on alternate-day fasting diets show reduced brain damage and mortality rate in rodent models of stroke 19, Am J Orthop ; 45 5: The manuscript should have an unstructured Abstract words representing an accurate summary of the article. Chapter in a book: Autologous chondrocyte implantation — A systematic review.Summary: The review protocol The protocol sets out in advance the methods to be used in the review with the aim of minimising bias.

The background section of the protocol should communicate the key contextual and conceptual factors relevant to the review question and. Video created by Johns Hopkins University for the course "Introduction to Systematic Review and Meta-Analysis". To get the ball rolling, we'll take a broad overview of what to expect in this course and then introduce you to the high-level.

Template for a Systematic Literature Review Protocol 1. Change Record This should be a list or table summarizing the main updates and changes embodied in each version of the protocol and (where appropriate), the reasons for these. 2. Background a) explain why there is a need for a study on this topic.

What is a Systematic Review

Dr. Joshua Harris, an orthopaedic surgeon in Houston & Baytown, TX specializes in arthroscopic surgery and sports injury treatment. Check for his practice locations. Systematic reviews and meta-analyses are essential to summarise evidence relating to efficacy and safety of healthcare interventions accurately and reliably.

The clarity and transparency of these reports, however, are not optimal. Poor reporting of systematic reviews diminishes their value to clinicians, policy makers, and other users. Since the development of the QUOROM (quality of reporting. This example was used to gather data for a poster reporting a literature review of studies of interventions to increase Emergency Department throughput.

How to write a systematic literature review protocol
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